Melatonin vs ZzzQuil Comparison - Drugs.com. Further, the product comes in gummy form that has a delicious lavender and lemon balm taste. My melatonin and valerian root stopped working (even though I gave myself a week holiday). Since the effect of both is the same, I recommend you get regular benadryl or diphenhydramine. 8 years ago. Anonymous. What's zzzquil? Melatonin. Relevance. Tried the ZZZquil last night and laid there for 3.5 hours before dozing off, then awake and tossing and turning every few minutes until morning. Not only that, it can help improve your body’s overall consistency across sleeping patterns. Quick Overview. Favorite Answer. Melatonin rated 6.1/10 vs ZzzQuil rated 2.0/10 in overall patient satisfaction. It has a sedative effect and can help you to get to sleep much easier. Both are over the counter caps you can buy from the brand Vicks. ZzzQuil Nighttime Sleep-Aid is an over-the-counter (OTC) medication that can help relieve occasional sleep problems. Melatonin is a naturally occurring hormone that helps regulate the sleep-wake cycle. Be sure to check tough! Conclusion – Unisom vs ZzzQuil. This is the first ingredient in ZzzQuil PURE Zzzs, and arguably the main one in this supplement. Both are first-generation antihistamines which can help to induce sleep. Ask your doctor for a good therapeutic dose of the melatonin first. Melatonin's more SPECIFIC for sleep induction than Nyqil which puts you out due to its side effects. Did not work for me at all. NO!!! But their effects are not. Taking Melatonin With ZzzQuil. However, some studies have concluded that doxylamine is the strongest sedative antihistamine. Melatonin is a herbal supplement that is taken to help with jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind and other sleep-wake cycle disturbances. Answer Save. Their names are similar. Just … Taking melatonin occasionally with ZzzQuil (diphenhydramine) is considered safe and there is no drug interaction between the two. Many Americans turn to sleep aids to relieve their insomnia. Vicks ZzzQuil PURE Zzzs Melatonin Gummies is a new formula that could work well to promote a good night’s sleep. The product is made with natural ingredients that are recognized for their sleep-promoting qualities. A solution - albeit a tad confusing - exists: ZzzQuil vs NyQuil. ZzzQuil is a brand name, and recently they have also expanded their product line with other products (such as ZzzQuil melatonin). There are two types of melatonin sold as an OTC remedy: one that is manmade and another that is derived from the pineal gland of animals. Compare Melatonin vs ZzzQuil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. So if I take melatonin and this zzzquil I just bought, would that be a safe combination first of all? Melatonin . The effectiveness of melatonin for sleep varies. The active ingredient in Unisom is doxylamine, whereas the active ingredient in ZzzQuil is diphenhydramine HCl. Melatonin is your body’s natural sleep hormone. They’ve caused a lot of confusion in the last couple of years. The reaction between them is to increase sleepiness. We’ll discuss: What the differences are between ZzzQuil and NyQuil : Are you talking about Nyquil (over the counter)? I recommend against that combo. But in general, if you see the name ZzzQuil, most of the time it will contain benadryl. And secondly would that put to sleep good tonight? 4 Answers. SCAMS just … Any input is appreciated.